Objectives

The overarching objective of WP3 is to get insights into how low and moderate doses of neutrons can influence the proliferation, differentiation and genome instability of stem cells and are therewith involved in radiation-induced carcinogenesis. After irradiation with either neutrons or with photons dose response relationships of different stem cell populations will be investigated in vitro and in vivo: 

• Determination of radiation effects on salivary and thyroid gland stem cells (task 3.1)
• Determination of radiation effects on breast tissue stem cells (task 3.2)
• Validation of track structure model (task 3.3

Workpackage leader

Dr Robert Coppes

University Medical Centre Groningen

E-mail: r.p.coppes@med.umcg.nl